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The method applied in this study is a quite new technique for cancer research and diagnosis, which provides a highly acceptable result, and recognized as a non-destructive, highly sensitive and specific analytical methods. The analytical approach was first reported by Petibois and Delereis, which presented several cancer markers. Cancer remains the most public health problems although scientist continuously focused on exploring the best anticancer agents to destroy the cancerous cells. National Center for Biotechnology Information , U. With further studies, the technique can be envisioned as a rapid and a sensitive diagnostic tool to help the pathologist in detecting skin cancer. Tel: , Fax: , E-mail: moc. Infrared spectra of normal and malignant Group I skin tissues of mice.

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