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Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. As well, they suggest possible novel treatments for sex hormone-dependent cancers. In addition, female mice demonstrated significantly lower levels of FSH and LH compared to wild-type mice. The neuroendocrine timing of puberty. In addition, mutant ovaries had a large number of atretic follicles when compared to wild-type.

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